Digital Humanities Data Curation

Digital Humanities Data Curation (DHDC) will engage scholars in sustained collaboration around issues of data curation in order to educate scholars on best practices and technologies for data curation and their relationship to scholarly methods. The Maryland Institute for Technology in the Humanities (MITH) at the University of Maryland will lead a collaboration partnering the Women Writers Project (WWP) at Brown University, and the Center for Informatics Research in Science and Scholarship (CIRSS) at the Graduate School of Library and Information Science (GSLIS), at the University of Illinois, Urbana-Champaign that will foster innovation in digital humanities research by integrating recent advances in the research and practice of data curation to address the specific needs of humanities researchers. DHDC will serve as an opportunity for participants to receive guidance in understanding the role of data curation in enriching humanities research projects

Robot kinematics: applications in virtual reality based pedagogy and sensor calibration

Conventions exist to describe the kinematics of a robot concisely, providing information about both its form and pose (position and orientation). Although mathematically convenient, the physical correlation between the parameters of these conventions and the robot that they represent is not necessarily intuitively obvious. Those who are new to the field of robotics may find it especially difficult to visualize these relationships. After presenting relevant background information on kinematics, robotics, virtual reality, and inertial sensors, this thesis investigates the effectiveness of using desktop virtual reality tools to help university-level students with the visualization of fundamental concepts in robot kinematics. Specifically, it examines how the new “Rotation Tool” assists students in the visualization of fixed and mobile frame compound rotations while verifying their non-commutative nature. It also explains how the new “Build-A-Robot” aids students in identifying the role that each of the Denavit-Hartenberg parameters plays in the description of the position and orientation of a serial manipulator’s component links. To enable flexible, real-time user interaction, Build-A-Robot employed a novel approach wherein MATLAB was used to directly manipulate the fundamental geometry of Virtual Reality Modeling Language (VRML) objects. Survey feedback and examination results are presented which indicate the students’ increased understanding that resulted after using both of these tools. This improvement was especially apparent among students who struggled to understand the concepts when traditional teaching methods alone were used. Tolerances in the manufacturing and assembly of robot arms introduce errors to the nominal kinematic models specified by manufacturers. This thesis also considers the impact of non-ideal kinematic parameters on the motion of the end-effector of a SCARA robot, which was used to calibrate an attached dual-axis accelerometer. Two novel, in-place calibration routines that employ dynamic accelerations are presented and validated using experimental data

USE OF PERIPHERAL VASOPRESSORS IN EARLY SEPSIS-INDUCED HYPOTENSION ACROSS MICHIGAN HOSPITALS

INTRODUCTION: Recent data suggest it may be safe to administer vasopressors via peripheral IV (PIV), challenging convention that vasopressors must be delivered centrally. Surviving Sepsis Campaign 2021 guidelines suggest using peripheral vasopressors as a bridge to central access. However, little is known about vasopressor initiation in practice. METHODS: Cohort study of patients hospitalized with community-onset sepsis at 12 hospitals in the Hospital Medicine Safety Consortium (HMS) sepsis initiative. HMS is a Collaborative Quality Initiative sponsored by Blue Cross Blue Shield of Michigan. A random sample of adult sepsis hospitalizations between 11/2020-1/2022 were included. Data were abstracted by trained abstractors. We sought to determine how commonly vasopressors were initiated via PIV vs central access across hospitals. HMS-Sepsis is expanding to 69 hospitals. Here we present pilot data; full cohort analysis is in process. RESULTS: of 1,901 patients in the HMS-Sepsis registry at the time of pilot data analysis, 440 (23.1%) had hypotension (defined by mean arterial pressure\u3c 65mmHg, systolic blood pressure\u3c 90mmHg, and/or vasopressor initiation) within 3 hours of hospital arrival. of these, 160 (36.4%) received vasopressors within 6 hours of hospital arrival. Route of initial vasopressor was PIV in 122 (76.3%), central access in 30 (18.8%), midline catheter in 1 (0.6%), oral (ie, midodrine) in 5 (3.1%), and unknown in 2 (1.3%). Across all hospitals, 50.0% to 91.7% of vasopressor initiation was via PIV (median 83.3%). Among 122 patients with vasopressor initiation via PIV, 66 (54.1%) received a 2nd vasopressor, after a median of 2.8 hrs [IQR 1, 8] from 1st vasopressor. Route of 2nd vasopressor was PIV in 27 (40.9%) and central access in 30 (45.4%). Time from hypotension to vasopressor initiation did not differ between patients receiving initial vasopressor via PIV vs central access (median 1.9 vs 2.1 hrs, p=0.79). Likewise, IV fluids within 6 hrs (median 2.0 vs 2.1L, p=0.78), hospitalization length (median 7 vs 6 days, p=0.31), and inhospital mortality (33.6% vs 40.0%, p=0.51) were similar. CONCLUSIONS: In this 12-hospital cohort, vasopressors were most frequently initiated peripherally. Outcomes were similar between patients in whom vasopressors were initiated via peripheral vs central access

Association of Infectious Disease Physician Approval of Peripherally Inserted Central Catheter With Appropriateness and Complications

Importance: Peripherally inserted central catheters (PICCs) are frequently used to deliver intravenous antimicrobial therapy. However, inappropriate PICC use may lead to patient harm. Objective: To evaluate whether infectious disease physician approval prior to PICC placement for intravenous antimicrobials is associated with more appropriate device use and fewer complications. Design, Setting, and Participants: This cohort study of 21 653 PICCs placed for a primary indication of intravenous antimicrobial therapy between January 1, 2015, and July 26, 2019, was conducted in 42 hospitals participating in a quality collaborative across Michigan among hospitalized medical patients. Main Outcomes and Measures: Appropriateness of PICCs was defined according to the Michigan Appropriateness Guide for Intravenous Catheters as a composite measure of (1) single-lumen catheter use, (2) avoiding use of PICCs for 5 days or less, and (3) avoiding use of PICCs for patients with chronic kidney disease (defined as an estimated glomerular filtration rate/min/1.73 m2). Complications related to PICCs included catheter occlusion, deep vein thrombosis, and central line-associated bloodstream infection. The association between infectious disease physician approval, device appropriateness, and catheter complications was assessed using multivariable models, adjusted for patient comorbidities and hospital clustering. Results were expressed as odds ratios with 95% CIs. Results: A total of 21 653 PICCs were placed for intravenous antimicrobials (11 960 PICCs were placed in men [55.2%]; median age, 64.5 years [interquartile range, 53.4-75.4 years]); 10 238 PICCs (47.3%) were approved by an infectious disease physician prior to placement. Compared with PICCs with no documented approval, PICCs with approval by an infectious disease physician were more likely to be appropriately used (72.7% [7446 of 10 238] appropriate with approval vs 45.4% [5180 of 11 415] appropriate without approval; odds ratio, 3.53; 95% CI, 3.29-3.79; P \u3c .001). Furthermore, approval was associated with lower odds of a PICC-related complication (6.5% [665 of 10 238] with approval vs 11.3% [1292 of 11 415] without approval; odds ratio, 0.55; 95% CI, 0.50-0.61). Conclusions and Relevance: This cohort study suggests that, when PICCs were placed for intravenous antimicrobial therapy, infectious disease physician approval of PICC insertion was associated with more appropriate device use and fewer complications. Policies aimed at ensuring infectious disease physician approval prior to PICC placement for antimicrobials may improve patient safety

Risk factors and outcomes associated with community-onset and hospital-acquired coinfection in patients hospitalized for coronavirus disease 2019 (COVID-19): A multihospital cohort study

BACKGROUND: We sought to determine the incidence of community-onset and hospital-acquired coinfection in patients hospitalized with coronavirus disease 2019 (COVID-19) and to evaluate associated predictors and outcomes. METHODS: In this multicenter retrospective cohort study of patients hospitalized for COVID-19 from March 2020 to August 2020 across 38 Michigan hospitals, we assessed prevalence, predictors, and outcomes of community-onset and hospital-acquired coinfections. In-hospital and 60-day mortality, readmission, discharge to long-term care facility (LTCF), and mechanical ventilation duration were assessed for patients with versus without coinfection. RESULTS: Of 2,205 patients with COVID-19, 141 (6.4%) had a coinfection: 3.0% community onset and 3.4% hospital acquired. Of patients without coinfection, 64.9% received antibiotics. Community-onset coinfection predictors included admission from an LTCF (OR, 3.98; 95% CI, 2.34-6.76; P \u3c .001) and admission to intensive care (OR, 4.34; 95% CI, 2.87-6.55; P \u3c .001). Hospital-acquired coinfection predictors included fever (OR, 2.46; 95% CI, 1.15-5.27; P = .02) and advanced respiratory support (OR, 40.72; 95% CI, 13.49-122.93; P \u3c .001). Patients with (vs without) community-onset coinfection had longer mechanical ventilation (OR, 3.31; 95% CI, 1.67-6.56; P = .001) and higher in-hospital mortality (OR, 1.90; 95% CI, 1.06-3.40; P = .03) and 60-day mortality (OR, 1.86; 95% CI, 1.05-3.29; P = .03). Patients with (vs without) hospital-acquired coinfection had higher discharge to LTCF (OR, 8.48; 95% CI, 3.30-21.76; P \u3c .001), in-hospital mortality (OR, 4.17; 95% CI, 2.37-7.33; P ≤ .001), and 60-day mortality (OR, 3.66; 95% CI, 2.11-6.33; P ≤ .001). CONCLUSION: Despite community-onset and hospital-acquired coinfection being uncommon, most patients hospitalized with COVID-19 received antibiotics. Admission from LTCF and to ICU were associated with increased risk of community-onset coinfection. Future studies should prospectively validate predictors of COVID-19 coinfection to facilitate the reduction of antibiotic use

Digital Humanities Data Curation [Interim Report: October 1, 2012 - July 31, 2013]

The Digital Humanities Data Curation (DHDC) institute series is a collaborative initiative led by the Maryland Institute for Technology in the Humanities in cooperation with the Women Writers Project, and the Center for Informatics Research in Science and Scholarship at the Graduate School of Library and Information Science (GSLIS), at the University of Illinois UrbanaChampaign. DHDC is designed to serve as an opportunity for humanities scholars with all levels of expertise—from beginners to the most advanced—to receive guidance in understanding the role of data curation in enriching humanities research projects. By the conclusion of each institute, participants will be adept in formulating solutions for existing challenges and will be able to document their data curation strategies in the form of a data curation plan and strategic risk assessment. The aggregation of resources and responses from across the institute’s three events will also create a cohort of scholars focused on discipline-specific curation practices and skills.National Endowment for the Humanitie

Engaging hospitalists in antimicrobial stewardship: Lessons from a multihospital collaborative

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/133542/1/jhm2599.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/133542/2/jhm2599-sup-0008-suppinfo08.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/133542/3/jhm2599_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/133542/4/jhm2599-sup-0011-suppinfo11.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/133542/5/jhm2599-sup-0006-suppinfo06.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/133542/6/jhm2599-sup-0009-suppinfo09.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/133542/7/jhm2599-sup-0007-suppinfo07.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/133542/8/jhm2599-sup-0012-suppinfo12.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/133542/9/jhm2599-sup-0010-suppinfo10.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/133542/10/jhm2599-sup-0005-suppinfo05.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/133542/11/jhm2599-sup-0004-suppinfo04.pd